Kashi Reddy Methuku

Kashi Reddy Methuku
Department of Chemistry and Biochemistry
University of Wisconsin-Milwaukee, WI,
USA

Dr Kashi Reddy working as Postdoctoral Research Associate at Department of Chemistry and Biochemistry University of Wisconsin-Milwaukee, WI, USA. He has done Ph.D from Organic & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad. Kakatiya University, Warangal, India under the guidance of Dr. Ahmed Kamal. The topic of his Thesis was “Synthesis and biological evaluation of new pyrrolobenzodiazepines, benzimidazoles and rutaecarpine derivatives as potential anticancer agents” The work is summarized as below: a. Synthesized more than 100 novel gene-targeting based pyrrolobenzodiazepine (PBD) hybrids with a view to improve anticancer activity. These newly synthesized PBD hybrids have been evaluated for their biological activity, DNA binding affinity. The most potent compounds were taken up for detailed studies and their apoptosis inducing ability were also investigated. b. Synthesized a library of novel terphenyl benzimidazoles, imidazopyridine-oxindoles, aminostilbene, chalcones, pyrimidine sulphonamides to explore their antitumour potential, inhibition of tubulin polymerization, and apoptosis inducing ability. c. Design and synthesized a series of novel oxadiazoles for their antitumor activity and inhibition of tubulin polymerization. d. Total synthesis of rutaecarpine and analogues by tandem azido reductive cyclization. He has authored- co/authored around 20+ papers, 7+ conferences proceedings, one patent and successfully contributed a charter “Pyrrolobenzodiazepines as Sequence Selective DNA Binding Agents” in Medicinal Chemistry and Drug Design Book. He has 2 years of teaching experience, received many awards and having reviewer and Editorial Board member role in many reputed journal.

Organic & Medicinal Chemistry, Physical science, Biological Science, Synthesis of pharmacologically interesting small and complex molecule entities, organic synthesis, heterocyclic chemistry, total synthesis of natural products and Analytical Technique.