A disease that persists for a long time. A chronic disease is one lasting four months or more, by the definition of the U.S. National Center for Health Statistics. Chronic diseases generally cannot be cured by medication or prevented by vaccines, nor do they just disappear. Chronic diseases will in general become increasingly normal with age. The leading chronic diseases in developed countries include (in alphabetical order) arthritis, disorder like heart attacks and stroke, cancer like breast and Carcinoma, diabetes, epilepsy and seizures, obesity, and oral health problems. Chronic conditions are often related to non-communicable diseases which are distinguished by their non-infectious causes. Some chronic conditions though, are caused by transmissible infections like HIV/AIDS.