Dangerous Effects of Pesticides to Humanity
Narayana A V V L*
Sri Vasavi Institute of Pharmaceutical Sciences, Tadepalligudem, West Godavari Dist, Andhra Pradesh-534101, India
- *Corresponding Author:
- Narayana A V V L
Sri Vasavi Institute of Pharmaceutical Sciences, Pedatadepalli, Tadepalligudem, West Godavari Dist, Andhra Pradesh-534101, India
Tel: +918341509491
E-mail: bobby.aitham@gmail.com
Received date: 26-06-2016; Accepted date: 20-07-2016; Published date: 26-07-2016
Visit for more related articles at Research & Reviews: Journal of Chemistry
Abstract
The use of toxic pesticides around the world to manage pest problems as becomes easy and common practice in agriculture field. Pesticides are using everywhere not only in agriculture field, but living areas like homes, parks, roads, schools etc. Our entire world is with full of pesticides, we can find anywhere in water, food, air, soil which causes dangerous effect to human health as well as to entire creature. The present review covers the toxic effect and dangerous problems are causing to entire world. The study suggest proper usage of pesticides to manage pest problems and as well as to minimize toxic condition to entire world.
Keywords
Pesticides, Pest Control, Toxic Effects, Soil.
Introduction
One of my favorite foods in this world has to be fresh fruits. Fruits are always packed with essential minerals and vitamins which improve our body health. That’s why our elders were used to say "An apple a day keeps the doctor away" and I believe that. When we are eating juicy fruits like Apple and Mango, we don’t think about how they become fruits? Now-a-days, farmers are using pesticides highly to control pest problems. All fruits and vegetables are sprayed with pesticides which can kill insects and control the pest problems. I surprised and I got a question, the same pesticides [1-17] are having potential effects on our body and environment? This question encourages me to dedicate a review on dangerous toxic effect [18-21] of pesticides on entire creature.
As we know all fruits and vegetables are grown in farms, then we can find lot of insects and bugs on the plants. The farmers don’t want to lose their crop by those small insects, so they can use pesticides and chemicals to kill them. Pesticides are preventing the spreading of diseases to entire crop, so farmers prefer pesticides to lower the risk of losing crop in that particular season. Not only farmer’s people are also using pesticides in the form of repellents [22], rodents [23-28] etc. By this way pesticides are exist in the system and it is one of the reasons for
Environmental Hazards and harmful to human health. There are so many effects of pesticides are following below.
Effect of Pesticides on Environment
Pesticides are mainly meant for killing pest and to protect crop from infectious diseases, but very large percentage
of pesticides are reaching their destination other than targeted place. They are easily entering into air, water, soil
and even into food.
Air and water: There are so many ways that pesticides are reaches into air and water by spraying, leaching [29-31],
runoff and May spilled accidently. An approximate two million metric tons of pesticides are used annually on
fields. Apart from this, stockpiles of old and outdated pesticides add to the trouble. Most of the farmers are
illiterate and use expired products. An estimated six to nine million metric tons of such pesticides are improperly
stored. So they are easily reaches rain, rivers, lakes and oceans.
Soil and plants: By spraying in the agriculture lands pesticides are reaches soil and plants and affecting them
drastically. They are affecting the agriculture land soil by harming useful micro-organisms, beneficial insects,
worms. They are affecting plant biochemistry and physiology by weakening plant immune system [32-42] and root
systems, and also reducing concentrations and effect of plant nutrients [43] such phosphorous [44,45] and nitrogen.
Animals and birds: By eating the food which is having pesticides spraying can harmful for animals and birds. The
over usage of pesticides may diminish food sources that some animals are need. Birds can be harm by eating
warms and insects which have consumed the pesticides. Now a day the pesticides are in the form of granules [46- 49] and the birds may eat them by mistaking them for grains of food.
Aquatic life: Fishes and other aquatic animals may be harmed by pesticide contamination of water. Reaching
pesticides into water May causes physiological and behavioral changes in fishes and aquatic animals.
Effect of Pesticides on Human Health
Pesticides are mainly designed to kill pest and insects. The mode of action of pesticides is not particularly specific
to any species, they often harm or kill organisms other than pest, including human. The World Health Organization
estimates that there are 3 million cases of pesticide poisoning each year and up to 2,20,000 deaths, primarily in
developing countries. We have to realize this, when we are eating fruit, we are also eating nearly 35 different
pesticides that have been sprayed on that. After many studies, pesticides are linked to cancer, birth defects and
also harm the reproductive system [50-53], the nervous system [54-63], and the endocrine system [64]. Children are at
risk when they exposed to pesticides because of their small size and they have not developed their nervous
systems and immune systems completely, they don’t have capable of fighting the entering of toxic pesticides into
their body systems.
Remedy for Pesticides Effect
The real solution for pesticides effects lays cultural methods and non-toxics methods of agricultural field.
Sustainable methods of pest control [65], pest management [66-69] and organically [70,71] grown food are the best ways to prevent pesticides to minimize the harm to environment [72-100] and human health.
Conclusion
By the entire study, we have to take some preventable cautions for proper usage of pesticides. The government bodies have to maintain proper regulatory system for pesticides. They should implement stricter independent testing of pesticides. We have to implement non-toxic pest management [66-69] programs in public places like parks, schools, roads etc.
References
- Xu L, et al. Mycotoxin Determination in Foods Using Advanced Sensors Based on Antibodies or Aptamers. Toxins 2016; 8: 239.
- Schnoor JL. Environmental Modeling: Fate and Transport of Pollutants in Water, Air, and Soil. Wiley-Interscience, New York, 1996.
- Accinelli C, et al. Pestic. Air Plant Soil Water Syst, Proc. 12th. Symp. Pestic. Chem; 2003.
- Hassink J, et al. Pestic. Air, Plant, Soil Water Syst, Proc. 12th. Symp. Pestic. Chem; 2003.
- Posthuma L, et al. Species Sensitivity Distributions in Ecotoxicology Environmental and Ecological Risk Assessment. Lewis Publisher, Boca Raton, USA, 2001.
- Goutailler G, et al. Photocatalysed degradation of cyromazine in aqueous titanium dioxide suspensions: comparison with photolysis. J Photochem Photobiol Chem. 2001; 141: 79-84.
- Bradbury SP and Coats JR. Comparative Toxicology of the Pyrethroid Insecticides. Rev Environ Contam Toxicol. Springer, New York, 1989.
- Tu S, et al. Synthesis and fungicidal activities of novel benzothiophene-substituted oxime ether strobilurins. Bioorg Med Chem Lett. 2014; 24: 2173-2176.
- Snoeck D, et al. The influence of different drying techniques on the water sorption properties of cement-based materials. Cement Concr Res. 2014; 64: 54-62.
- Delli CHT and Doering IW. Pesticide Formulations and Application Systems. ASTM International, West Conshohocken, PA, 2001; 12: 141-151.
- Kronhardt A, et al. Chloroquine Analog Interaction with C2- and Iota-Toxin in Vitro and in Living Cells. Toxins 2016; 8: 237.
- Hall S, et al. Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa. Toxins 2016; 8: 236.
- Sanzani SM, et al. A Rapid Assay to Detect Toxigenic Penicillium spp. Contamination in Wine and Musts. Toxins 2016; 8: 235.
- Li Y H, et al. Putative Nonribosomal Peptide Synthetase and Cytochrome P450 Genes Responsible for Tentoxin Biosynthesis in Alternaria alternata ZJ33. Toxins 2016; 8: 234.
- Clemons NC, et al. Selective Membrane Redistribution and Depletion of Gαq-Protein by Pasteurella multocida Toxin. Toxins 2016; 8: 233.
- Kaplan G, et al. Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A. Toxins 2016; 8: 217.
- Liu L, et al. Modified lignin sulfonate adhesives compatible WG into granulocytes. Agrochemicals 2011; 50: 720-723.
- Laustsen AH, et al. Biotechnological Trends in Spider and Scorpion Antivenom Development. Toxins 2016; 8: 226.
- Junqueira DA, et al. Colubrid Venom Composition: An Omics Perspective. Toxins 2016; 8: 230.
- Lai Y, et al. Purification and Characterization of a Novel Kazal-Type Trypsin Inhibitor from the Leech of Hirudinaria manillensis. Toxins 2016; 8: 229.
- Anastassiades M, et al. Fast and Easy Multiresidue Method Employing Acetonitrile Extraction/Partitioning and “Dispersive Solid-Phase Extraction” for the Determination of Pesticide Residues in Produce. J AOAC Int. 2003; 86: 412-431.
- Chougale VV and Deshmukh AM. Biodegradation of carbofuran pesticide by saline soil actinomycetes. Asian J Micro Biotech. Environ Sci. 2007; 9: 1057-1061.
- Escobedo G, et al. Theoretical Study of 8-Chloro-9-Hydroxy-Aflatoxin B1, the Conversion Product of Aflatoxin B1 by Neutral Electrolyzed Water. Toxins 2016; 8: 225.
- Kopfmann S, et al. Type II Toxin–Antitoxin Systems in the Unicellular Cyanobacterium Synechocystis sp. PCC 6803. Toxins 2016; 8: 228.
- Fernández G, et al. Toxin-Antitoxin Systems in Clinical Pathogens. Toxins 2016; 8: 227.
- Duringer J, et al. No Association between Mycotoxin Exposure and Autism: A Pilot Case-Control Study in School-Aged Children. Toxins 2016; 8: 224.
- Silva MC, et al. Interaction between TNF and BmooMP-Alpha-I, a Zinc Metalloprotease Derived from Bothrops moojeni Snake Venom, Promotes Direct Proteolysis of This Cytokine: Molecular Modeling and Docking at a Glance. Toxins 2016; 8: 223.
- Fernández B, et al. Mapping Protein–Protein Interactions of the Resistance-Related Bacterial Zeta Toxin–Epsilon Antitoxin Complex ε2ζ2 with High Affinity Peptide Ligands Using Fluorescence Polarization. Toxins 2016; 8: 222.
- Faïs T, et al. Impact of CDT Toxin on Human Diseases. Toxins 2016; 8: 220.
- Schnell L, et al. Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication. Toxins 2016; 8: 221.
- Faltermann S, et al. Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish Danio rerio.Toxins 2016; 8: 219.
- Ramales V, et al. Biosorption of B-aflatoxins Using Biomasses Obtained from Formosa Firethorn [Pyracantha koidzumii Hayata Rehder]. Toxins 2016; 8: 218.
- Matthews GA. Determination of droplet size. Pest Art News Sum. 1975 21: 213-225.
- Malaquin S, et al. Respiratory Effects of Sarafotoxins from the Venom of Different Atractaspis Genus Snake Species. Toxins 2016; 8: 215.
- Muthuramalingam M, et al. Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways. Toxins 2016; 8: 214.
- Shi D, et al. A New Myotropic Tryptophyllin-3 Peptide Isolated from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea. Toxins 2016; 8: 213.
- Burgos M, et al. Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid. Toxins 2016; 8: 211.
- Feyereisen R. Insect Molecular Biology and Biochemistry. Academic Press, San Francisco, 2012, 8: 236-316.
- Hershey AE. Ecology and Classification of North American Freshwater Invertebrates. Academic Press, San Francisco, USA, 2010, 17: 659-694.
- Estenik JF and Collins WJ. Pesticide and Xenobiotic Metabolism in Aquatic Organisms. ACS Symp Ser 99, American Chemical Society, Washington D.C, 1979, 21: 349-370.
- Debono J, et al. Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms. Toxins 2016; 8: 210.
- Zhao Z, et al. Distribution and Metabolism of Bt-Cry1Ac Toxin in Tissues and Organs of the Cotton Bollworm, Helicoverpa armigera. Toxins 2016; 8: 212.
- Vontas J, et al. Insecticide resistance in Tephritid flies. Pestic Biochem Physiol. 2011; 100: 199-205.
- Dunyach R, et al. Staphylococcus aureus Toxins and Diabetic Foot Ulcers: Role in Pathogenesis and Interest in Diagnosis. Toxins 2016; 8: 209.
- Matusova R, et al. The Strigolactone Germination Stimulants of the Plant-Parasitic Striga and Orobanche spp. are Derived from the Carotenoid Pathway. Plant Physiol. 2005; 139: 920-934.
- Botana LM, et al. How Safe Is Safe for Marine Toxins Monitoring? Toxins 2016; 8: 208.
- Ohtani K and Shimizu T. Regulation of Toxin Production in Clostridium perfringens. Toxins 2016; 8: 207.
- Hammouda M B, et al. A Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells. Toxins 2016; 8: 206.
- Heo Y, et al. Cloning a Chymotrypsin-Like 1 CTRL-1 Protease cDNA from the Jellyfish Nemopilema nomurai. Toxins 2016; 8: 205.
- Zhang F, et al. The Stress Response Regulator AflSkn7 Influences Morphological Development, Stress Response, and Pathogenicity in the Fungus Aspergillus flavus. Toxins 2016; 8: 202.
- Natalia TG, Robert MH, Life-Cycle Assessment of Neonicotinoid Pesticides. J Fertil Pestic. 2016 7: 165.
- Uqab B, et al. Review on Bioremediation of Pesticides. J Bioremed Biodeg. 2016; 7: 343.
- Ghorab MA and Khalil MS. The Effect of Pesticides Pollution on Our Life and Environment. J Pollut Eff Cont. 2016; 4: 159.
- Jamal F, et al. The Influence of Pesticides on Hepatic and Renal Functions in Occupational Sprayers of Rural Malihabad, Lucknow India. Toxicol open access 2016; 2: 107.
- SK VC and Urvinder Kaur S. Pesticides Detection Using Acetylcholinesterase Nanobiosensor. Biosens J. 2016; 5: 133.
- Covaci AC, et al. Influence of Meat Processing on the Content of Organochlorine Pesticides. J Food Process Technol. 2015; 6: 517.
- Raja N, Masresha G, Plant Based Biopesticides: Safer Alternative for Organic Food Production. J Biofertil Biopest. 2015; 6:128.
- Kumar S and Singh A. Biopesticides: Present Status and the Future Prospects. J Biofertil Biopest. 2015; 6: 129.
- Nasr HM. Toxicity and Biochemical Effect of Organophosphates and Bio-pesticides against Root-knot Nematode, Meloidogyne incognita. J Pollut Eff Cont. 2015; 4: 151.
- Gbeddy G, et al. Assessment of Organochlorine Pesticides in Water, Sediment, African Cat fish and Nile tilapia, Consumer Exposure and Human Health Implications, Volta Lake, Ghana. J Environ Anal Toxicol. 2015; 5: 297.
- Abdel lKS, et al. Monitoring of Molecular Variation among Egyptian Faba Bean Rhizobium Isolates as Response to Pesticides Stress. J Bioremed Biodeg. 2015; 6: 296.
- Khalil MS. Fate of Pesticides in the Agricultural Environment. Biol Med. 2014; 7: 117.
- Begna D, Assessment of Pesticides Use and its Economic Impact on the Apiculture Subsector in Selected Districts of Amhara Region, Ethiopia. J Environ Anal Toxicol. 2015; 5: 267.
- Cizmas L, Measurement of Organophosphate Pesticides, Organochlorine Pesticides, and Polycyclic Aromatic Hydrocarbons in Household Dust from Two Rural Villages in Nepal. J Environ Anal Toxicol 2015; 5: 261.
- Sarkar M and Kshirsagar R, Botanical Pesticides: Current Challenges and Reverse Pharmacological Approach for Future Discoveries. J Biofertil Biopesti. 2014; 5: 125.
- Bendetti D, et al. An Evaluation of Occupational Exposures to Pesticides in Brazil. Occup Med Health Aff. 2014; 2: 170.
- Batool Z and Haque A, Structure Prediction of Delta Aminolevulinic Acid Dehydratase ALAD; An Enzyme that is Very Sensitive to the Toxic Effects of Lead. J Biom Biostat. 2015; 6: 259.
- Chgoury F, et al. Effectiveness of the Androctonus Australis Hector Nanobody Nbf12-10 Antivenom to Neutralize Significantly the Toxic Effect and Tissue Damage Provoked by Fraction of Androctonus mauretanicus Morocco Scorpion Venom. Biochem Pharmacol. 2015; 4: 174.
- Tripathi BD and Tripathi DM, Toxic Effects of Distillery Sludge Amendment on Microbiological and Enzymatic Properties of Agricultural Soil in a Tropical City. J Environment Analytic Toxicol. 2011; 1:102.
- Tripathi BD, A Short Term Study on Toxic Effects of Distillery Sludge Amendment on Microbiological and Enzymatic Properties of Agricultural Soil in a Tropical City. J Earth Sci Climat Change. 2011; 1: 106.
- Karunamoorthi K, Plant-Based Insect Repellents: Is That a Sustainable Option to Curb the Malaria Burden in Africa? Medicinal Aromatic Plants. 2012; 1: 106.
- Sharmaa N, et al. Protective Effect of a Standardized Fraction from Vitex negundo Linn. Against Acetaminophen and Galactosamine Induced Hepatotoxicity in Rodents. Biochem Anal Biochem. 2016; 5: 267.
- Ozolua RI, et al. Evaluation of the Anti-asthmatic and Antitussive Effects of Aqueous Leaf Extract of Ocimum gratissimum in Rodents. Med Aromat Plants. 2016; 5: 235.
- Ozolua RI, et al. Extract of Garcinia kola Seed has Antitussive Effect and Attenuates Hypercholesterolemia in Rodents. Med Aromat Plants. 2016; 5: 232.
- Pogun S, et al. Oral Nicotine Self- Administration in Rodents. J Addict Res Ther. 2012; S2: 004.
- Wang Z and Zhang H. Antidiabetic Effects of Ginseng in Humans and Rodents. J Metabolic Synd. 2012; 1: 106.
- Taaheri SM, et al. Effects of Docosahexaenoic Acid in Preventing Experimental Choroidal Neovascularization in Rodents. J Clinic Experiment Ophthalmol. 2011; 2: 187.
- Jeon TW, et al. A Study on Leaching Property of Hazardous Substances in Coal Ash Through the Column Test Percolation test. J Environ Anal Toxicol. 2016; 6: 354.
- MMA EG and Bondkly AMAE. Optimization of Solid State Fermentation and Leaching Process Parameters for Improvement Xylanase Production by Endophytic Streptomyces sp. ESRAA-301097. J Microb Biochem Technol. 2014; 6: 154-166.
- Muslim A. Adsorption of Copper Complexes on Anion Exchange Resin in Non-Ammoniacal and Ammoniacal Thiosulfate Leaching Systems. J Chem Eng Process Technol. 2012; 3: 121.
- Melamed I. Alzheimer’s disease of the Immune System: A New Variant of Immune Deficiency. Immunother Open Acc. 2016; 2: 115.
- Allen HB, et al. Alzheimer’s disease: A Novel Hypothesis Integrating Spirochetes, Biofilm, and the Immune System. J Neuroinfect Dis. 2016; 7: 200.
- Boukelia B. Exercise, Immune System and Circadian Rhythm. J Sports Med Doping Stud. 2015; 5: 163.
- León TEJ and Torres ER. IV García, Immune System and Pituitary Tumors: TILs Death tears them apart. A Review. J Cytol Histol. 2015; 6: 332.
- Turhan A. Immune System Behavior during Herpesvirus Infection in Childhood. J Infect Dis Ther. 2014; 2: 104.
- Stamenkovic H, et al. Immune System Behavior during Herpesvirus Infection in Childhood. J Infect Dis Ther. 2014; 2: 162.
- Kallick RCA. The Potential Relationship of the Ehrlichia to Immune System Dysfunction: Etiology and Pathogenesis. Rheumatology. 2014; 4: 128.
- Karacabey K and Ozdemir N. The Effect of Nutritional Elements on the Immune System. J Obes Wt Loss Ther. 2012; 2: 152.
- Theron AJ, et al. Harmful Interactions of Non- Essential Heavy Metals with Cells of the Innate Immune System. J Clinic Toxicol. 2012; S3: 005.
- Perez GLA, et al. Role of Cell Wall Polysaccharides during Recognition of Candida albicans by the Innate Immune System. J Glycobio. 2011; 1: 102.
- Logani MK, et al. Millimeter Wave and Drug Induced Modulation of the Immune System -Application in Cancer Immunotherapy. J Cell Sci Ther. 2011; S5: 002.
- White JF, et al. Nutritional Endosymbiotic Systems in Plants: Bacteria Function like ‘Quasi-Organelles’ to Convert Atmospheric Nitrogen into Plant Nutrients. J Plant Pathol Microb. 2012; 3: 104.
- Chen Y, et al. Effects of Nitrogen and Phosphorous Fertilization on Western Flower Thrips Population Level and Quality of Susceptible and Resistant Impatiens. Adv Crop Sci Tech. 2014; 2: 145.
- Eubanks DL. Plasma Calcium, Phosphorous and Magnesium Levels in Cats with and without Tooth Resorption. J Veterinar Sci Technol. 2011; S3: 001.
- Guettala S, et al. Properties of the Compressed-Stabilized Earth Brick Containing Cork Granules. J Earth Sci Clim Change. 2016; 7: 353.
- Liang L, et al. Comparative Study on Fluorescence Spectra of Chinese Medicine North and South Isatis Root Granules. Nat Prod Chem Res. 2016; 4: 201.
- Drakides C and Lay SM. Aerobic Granules Formation in Dual- Layer Percolating Filters. J Civil Environment Engg 2012; 2: 112.
- Singh J, et al. Pharmacological Efficacy of Insulin- Loaded Granules Made Up of Various Grades of Hydroxypropyl Methylcellulose in Normal Rats. J Bioequiv Availab. 2015; 07: 257-261.
- Sayed AEDH, Evaluation of Apoptotic Cell Death and Genotoxicty Following Exposure to Silver Nanoparticles in African Catfish Clarias gariepinus. Toxicol open access 2016; 2: 109.
- Chen Y, et al. Effects of Nitrogen and Phosphorous Fertilization on Western Flower Thrips Population Level and Quality of Susceptible and Resistant Impatiens. Adv Crop Sci Tech. 2014; 2: 145.