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A NEW RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND FENOFIBRATE IN ITS BULK AND TABLET DOSAGE FORM

Abstract

 A New method was established for simultaneous estimation of Atorvastatin And Fenofibrate by RP-HPLC method. Methods: Chromatographic separations were carried using Phenomenex C18 column (4.6x250mm,5µm) column with a mobile phase composition of 0.1 M Ammonium acetate:acetonitrile (60:40) have been delivered at a flow rate of 1ml/min and the detection was carried out using waters HPLC auto sampler, separation module 2695 with PDA detector at wavelength 236 nm. Results: The retention time for Atorvastatin And Fenofibrate were 2.991 and 5.931 minute respectively. The correlation coefficient values in linearity were found to be 0.999 and concentration range 10-30 μg/ml for Atorvastatin and 160-480 µg/ml for Fenofibrate respectively. For accuracy The total recovery was found to be 99.08% and 100 % for Atorvastatin And Fenofibrate. Conclusion: The results of study showed that the proposed RP‐HPLC method is a simple, accurate, precise, rugged, robust, fast and reproducible, which may be useful for the routine estimation of Atorvastatin And Fenofibrate in pharmaceutical dosage form

M.Sowmya, S.K.Godasu, B.Nagaveni, P.Raju, R.Suneetha

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