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A Potent Pre-Medication in Periodontal Surgical Procedures - Ketorolac Tromethamine 10mg: A Randomized Controlled Trial

Abstract

Oral ketorolac tromethamine (KT) in 10 and 20mg postoperative doses in an oral surgery pain model have proven to be equally analgesic as 400mg ibuprofen, and significantly better than acetaminophen and acetaminophen-codeine combinations. It prevents pain by blocking arachidonic-acid pathway. To evaluate the analgesic effect of preoperative KT-10mg, on pain during and after open flap debridement (OFD) surgery. 42-patients were randomized (21-controls, 21-tests). Oral KT-10mg was given to test-group 10 minutes before administration of the local-anesthesia (L.A), prior to OFD. Visual analogue scale (VAS) was used to assess pain, immediately after OFD, and every hour after that until, first onset of pain, & time of onset of pain. The mean values of time of onset of pain in test-group was 3.57 hours, while it was 2.33 hours in the control-group (p=0.005). KT-10mg pre-medication was effective in pain reduction during surgery. However, it neither affected delayed pain levels, nor postoperative analgesic consumption.

Monali A Shah, Jay Patel, Sneha S Shah, and Deepak H Dave

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