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A Review: Roller Compaction for Tablet Dosage Form Development

Abstract

Roller compaction is a unit operation in dry granulation process in which the powders containing active ingredients and excipients are agglomerated between the rollers of compactor. During roller compaction the dry powders of the active ingredients and excipients are blended in a blender and further roller compacted and milled to form granules. The resulting granules are then blended within in a blender and used for compression into tablets or for capsule filling. Compaction of powder is the term used to describe the situation in which these materials are subjected to some level of mechanical force. In pharmaceutical industries, the effects of such forces are very important in manufacturing of granule and tableting. The compaction is generally divided into two states compression and consolidation. Compression is nothing but the reduction in bulk volume of material by plastic deformation. The main purpose of roller compaction is to Improve powder flow properties, avoid wet granulation induced degradation, improve product stability, prevent segregation, reduce bulk volume hence minimizes storage volume and hence improves transport efficiencies and to reduce potential environmental hazards and ensures safety. Dis-advantages of roller compaction are densification of the powder or particle which can adversely affects the dissolution of product and the powder to be compacted must be compressible or have to add compressible excipients or additives to the formulation. Sophistications available with roller compaction system are roller cooling or heating, vacuum de aeration, Separate feed funnel for small quantities of powders and Pneumatic dry granulation.

Dhuma Sonam1, Kulkarni PA, Kashikar VS, Baweja Jitendra, and Thottasseri Manoj

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