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Antioxidant and Protective Effects of Chloroxylon Swietenia in L-Thyroxine Induced Hyperthyroidism in Rats

Abstract

This study was performed to evaluate the anti-hyperthyroid effects and action mechanism of Chloroxylon Swietenia, a medicinal herb, on levothyroxine (LT4)-induced hyperthyroidal rats. Wistar rats were divided into five groups, namely, thyroidal normal group (normal), hyperthyroidism control group (disease control), hyperthyroidism plus Propylthiouracil treated group (PTU) as a standard, hyperthyroidism plus 200 mg/kgm ethanolic extract of Chloroxylon Swietenia (MECS) treated group, and hyperthyroidism plus 400 mg/kg MECS-treated group. The rats in groups other than normal were injected with LT4 for 12 days to induce hyperthyroidism and then were administrated each treatment for 17 days. Biochemical parameters related to hyperthyroidism were examined. Compared with the disease control group, serum T₃ and T₄ levels were significantly reduced in the test and PTU treated groups where as serum TSH levels and body weight were significantly increased in the test and PTU treated groups. These results suggest that Chloroxylon Swietenia has the potential to decrease T₃, T₄ levels and enhance the levels of Thyroid Stimulating Hormone (TSH) and body weight of the animals and therefore, Chloroxylon Swietenia could be an alternative therapy for hyperthyroidism. Phytoconstituents like flavonoids, alkaloids, phenols and terpenoids present in the Chloroxylon Swietenia leaf extract might be responsible for the beneficial effect in hyperthyroidism.

Veeresh Babu Pratap, Saipriya Vemula, Ganga Raju Mudunuri

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