Review Article Open Access

Atherosclerosis: An Increased Risk for Cancer

Abstract

Cardiovascular diseases especially atherosclerosis is the leading purpose of morbidity and mortality internationally due to thrombotic occlusion of a inclined plaque. Early assessment of atherosclerotic lesions is an important diagnostic tool so as to decrease the coronary artery blockage. Cell adhesion molecules like integrins and cadherin-catenins if altered results in plaque formation and thrombosis which in turn leads to invasion of tumour and metastasis. An imbalance in macrophage activation polarization with prevalence of M1 phenotype is observed because of the deposition of lipids in the adipose tissue. Toxic metabolites produced by cigarette smoking and extended fat intake are entangled in the pathogenesis of atherosclerosis and cancer. A hypothesis is made that atherosclerosis can be initiated with a damage or mutation of proliferative clone held to the concept of carcinogenesis. These modifications may additionally make a contribution to the improvement of atherosclerosis and most cancers.

Nikhila Vengala

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