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Clinical Evaluation of Topical Application of Doxycycline 3% + Ketoprofen 2.5% Gel in Chronic Periodontitis Patients

Abstract

Objectives: 1. To evaluate the clinical effects of localized doxycycline 3% + ketoprofen 2.5% (Dox+Keto) gel as an adjunct to scaling and root planing (SRP) in the treatment of periodontitis. 2. To encourage the use of subgingival (Dox+Keto) gel as an adjunct to conventional periodontal therapy. Materials and Methods: A total of twenty patients were enrolled. A split-mouth design was carried out; the patients were categorized into two discussion groups: group A: SRP plus (Dox+Keto); group B: SRP plus keto respectively. Clinical parameters such as a plaque index (PI), bleeding index (BI), probing pocket depth (PPD), clinical attachment level (CAL) were assessed at baseline, 1 month and 3 months. The results were subjected to statistical analysis, which was expressed as mean ± SD and proportions as percentages. Intragroup comparisons were made by paired t-test and one-way analysis of variance (ANOVA) for inter-group comparisons. Results: The intragroup analysis showed a significant reduction (P<0.05) of clinical periodontal parameters in all two treatment groups. Moreover, the inter-group analysis manifested, that intra-pocket (Dox+Keto) gel application in combination with SRP showed a significant reduction while no statistically significant difference was observed in the second group (SRP with intra-pocket Keto gel alone). Conclusion: In this study, SRP with (Dox+Keto) gel exhibited clinical results with statistically significant differences. As it appears, (Dox+Keto) gel in this study may have a potential additive effect.

Amirhossein Farahmand, Ferena Sayar, Reza MazlomTehrani and Bahareh Jafarzadeh Esfahani

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