Research Article Open Access

Comparative Study on the Efficiency of Various Binder Combinations for Metformin Tablets

Abstract

Metformin hydrochloride is widely used as an oral anti hypoglycemic agent. But it is difficult to formulate by direct compression method because of its poor compaction properties and its crystalline nature. The present study target for a better combination of binders that produces metformin tablets with unique results. The granulation is done using binder combination of gelatin, PVP K 30, HPMC, Cross Povidone, starch and Kyron-T 314. The wet granulation method is selected for the formulation of metformin tablets and the formulated tablets were evaluated for their hardness, friability, disintegration, content uniformity and dissolution profiles with USP type II apparatus at 100 rpm in pH 6.8 phosphate buffer solution. The Formulation F2 (containing gelatin and HPMC as binders) demonstrated unique results than the other formulations. The formulation F5 (containing gelatin and Kyron-T 314 as binders) shows faster disintegration than the other formulations but shows least hardness.

Gunturu Abhilash, Beny Baby, B Prakash Rao, S Raja Rajan, K Ramesh and G Ravi Kumar

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