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A liposome is a tiny bubble spherical vesicle, made of cell membrane which are filled with drugs and used to deliver drugs diseases such as cancer used as a vehicle for administration of nutrients. The latest advances in liposome research allows liposomes to avoid detection by the body's immune system, such as the cells of reticuloendothelial system. These liposomes are known as "stealth liposomes". Targeted liposomes can target nearly any cell type in the body and deliver drugs that would otherwise be systemically delivered. Research on liposome technology has progressed from conventional vesicles to ‘second-generation liposomes’, in which long-circulating liposomes are obtained by modifying the lipid composition, size, and charge of the vesicle. The purpose of this article is to discuss the use of drug delivery systems, especially liposomes, to solve the problem of non-specific distribution of drugs through tumour targeting.