Research Article Open Access

Direct Analysis of Substandard Antibiotics Sensitivity Pattern against Common Isolates of Pathogens via Modified Oucherlony Technique: A in vitro Study in Karachi

Abstract

Introduction: Medicines are blessing for mankind, which use for treating, curing the disease and deliver relieve in pain and manage the illness sign and symptoms. There are varieties of substitute present in the market of same generic medicines. Some are cost-effective, several are substandard in quality; some are inefficient in efficacy and ultimately are not yielding same effect against the claim. The purpose of the study is to explore the differences in the quality of locally manufactured antibiotics in Pakistan by using modified Oucherlony technique.

Design and participants: In order to conduct this Pilot study, 3 samples of antibiotics from interior and frontier areas of Pakistan were selected as candidate medicines.

Measurements: Data source is primary and samples are randomly collected addressing the research objective. Modified Oucherlony double immunodiffusion technique is used to assess antibacterial and bacteria resistance susceptibility pattern of 3 brands of locally manufactured cheap price medicines against the commonly isolates UTI pathogens.

Findings and conclusion: This study shows that out of three brands of antibiotics, two of the brands of azithromycin are highly resistant against the UTI pathogens; however one of the brands are resistant to S. aureus, Acinetobacter, E. coli but little activity showed in the enterococcus bacteria.

Hina Sharif*, Sana Sharif, Haroon Diwan

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