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Enhanced Bioavailability of 6-[3-(4- chlorophenyl)-1H-pyrazol-4-yl]-3-[(2- naphthyloxy) methyl][1,2,4] triazolo[3,4- b][1,3,4] thiadiazoleon C6 Cell Lines using Chitosan Encapsulation at Nano Scale

Abstract

Biodegradable nano size biopolymers have important potential applications for administration of therapeutic molecules. The aim of the present investigation was to demonstrate the synthesis and characterization of biodegradable nanoparticles based on chitosan for encapsulation of a novel water insoluble drug 6-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy) methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (CPNT). Drug containing nanoparticles were prepared with different amounts of chitosan using ionic gelation method. The mean size and size distribution of nanoparticles were measured by dynamic laser light scattering and confirmed with Scanning Electron Microscope (SEM). The mean particle size, varied in the range of 117- 122 nm. The maximum encapsulation efficiency of 75% was encountered using drug:polymer ratio of 1:10. IC50 value of chitosan encapsulated CPNT was five times less than non-encapsulated drug and was almost 24 times less than the standard doxorubicin drug.

Keyur Raval, Dhanya Sunil, Sakshi Singhania, Praful Deshpande

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