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Evaluation of Diuretic Activity of Extracts of Gentiana oliveri and Gentianine in Rats

Abstract

Biological and pharmacological assays of the extracts of Gentiana oliveri and its alkaloid gentianine proved to be highly efficacious. Extracts of Gentiana oliveri and gentianine were evaluated for diuretic activity in normotensive, rats. Oral administration of all the fractions enhanced ion excretion. A dose-dependent diuresis and electrolytes excretion was also observed when dose by gentianine. There was marked increase in Na+, K+ and Cl- ion excretion in the aqueous extract as compared to control and furosemide. Significant increase in urinary excretion was produced by pure alkaloid (P<0.04), ethanolic extract (P<0.03), aqueous extract (P<0.01) and furosemide (P<0.001). Gentianine could be developed as a safe antihypertensive drug.

Arsala Mansoor, Sohaib Huda and Mudassir Asrar

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