Review Article Open Access

Fast Dissolving Tablet of Terbutaline Sulfate: Review

Abstract

Received:10-07-2016 Revised: 12-08-2016 Accepted:18-08-2016 *Corresponding author: Shakeena G, Department of Pharmaceutical Analysis and Quality Assurance, Green Royal Academy Of Pharmaceutical Education & Sciences, Ponguturu, Koyyalagudem, West Godavari–534312, Andhra Pradesh, India, Tel:9949581690. Email: shakeena.gadde@gmail.com Keywords: Fast dissolving tablet, Microcrystalline cellulose, Oral route, Sodium starch glycolate, Terbutaline sulfate. ABSTRACT Terbutaline sulfate is employed to treat respiratory disease and respiratory disorders. Terbutaline belongs to a category of beta-adrenergic agonist bronchodilators. It is a β2 blocker used to treat cardiovascular diseases like high blood pressure, cardiopathy, and disturbances of regular recurrence, myocardial infarct and purposeful heart disorders. Fast dissolving tablets of terbutaline sulfate is ready by adding crystalline cellulose and sodium starch glycolate. Terbutaline sulfate half-life is 2-3 hours oral availability is 38 ± 14 % and it's eliminates quickly from plasma, microcrystalline cellulose and sodium starch glycolate was discharged 95.2% and 96.8% of drug at intervals 8-10 min. These tablets are used for patients who might have problem in swallowing of typical tablets; frequent administration is required to take care of therapeutic concentration. Fast dissolution and absorption of drug might turn out rapid onset of action. Fast dissolving drug delivery systems FDDDSs that disintegrate and release the active ingredient quickly which don't need water for swallowing. Oral administration of bitter medication with associate adequate degree of palatableness is achieved by taste masking. Fast dissolving tablet FDT is employed as super disintegrants which can give immediate disintegration and releases the drug in saliva. Fast dissolving tablets of terbutaline sulfate tablets are ready by the direct compression technique once incorporating with super disintegrants similar to crystalline cellulose and sodium starch glycolate in numerous concentrations. evaluation for prepared tablets were weight variation, thickness, hardness, friability, wetting time, drug content, water absorption quantitative relation, in vitro dispersion time, in vitro disintegration time and in vitro drug release..

Shakeena Gadde

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