Research Article Open Access

Formulation and Evaluation of Metoclopramide Hydrochloride Sustained Release Microsphere.

Abstract

The aim of the present work is to develop the Metoclopramide hydrochloride microsphere using Eudragit RL 100 and hydroxyl propyl methyl cellulose (HPMC K100) as a polymer by solvent evaporation method for Sustained effect. For the preparation of Metoclopramide Hydrochloride Microsphere the solvent system i.e., (Dichloromethane and ethanol) and the drug–polymer ratio are use in various concentrations, to obtain the desire sustained formulation. Various formulation of metoclopramide hydrochloride microsphere was formulated by using Eudragit RL 100 and HPMC K100 polymers. The microsphere was evaluated for physical characterizations angle of repose, particle size, drug entrapment efficiency, in-vitro dissolution. Results of all the physical and in-vitro dissolution data concluded in that formulation E-6 was the most promising formulation. The E-6 batch microsphere prepared from the Eudragit RL100 polymer in that the drug-polymer ratio is 01:1.5, and 01:01 Solvent system (DCM: Ethanol), using 2% span 80 as dispersing agent. Metoclopramide hydrochloride microsphere E-6 formulation releases the maximum drug i.e., 95.87 ± 0.70 for 12 hrs. The kinetic study was carried out and the best fitted kinetic model for E6 optimised batch was Korsmeyer peppas have R value 0.998 and k value was 13.62.

Bharat W Tekade, Umesh T Jadhao, Vinod M Thakare, Kundan P Chaudhari, and Harshal B Kedare

To read the full article Download Full Article | Visit Full Article