Research Article Open Access

Formulation and Evaluation of Orodispersible Tablets of Salbutamol Sulphate

Abstract

Salbutamol sulphate is a selective β2-adrenergic agonist and represents an effective drug for the treatment of asthma and the symptomatic alleviation of bronchospasm. Orodispersible tablets of Salbutamol sulphate were prepared using croscarmellose sodium, sodium starch glycolate, alginic acid, modified agar and modified guar gum as superdisintegrants. Precompression parameters were carried out to study the flow properties of powder to achieve uniformity of tablet weight and the values were within permissible limits. The tablets were prepared by direct compression method and possess a weight variation below ± 7.5%, hardness of 3.09 to 3.55 Kg/cm2, percentage friability of 0.310 to 0.698, in-vitro dispersion time of 22 to 54 seconds. The drug content uniformity was in between 95.94 to 99.67%, water absorption ratio of 58.58 to 87.06%, wetting time of 18 to 49.66 seconds and in vitro drug release showed that, more than 85% of the drug was released from all formulations within 15 min and revealed that the prepared tablets were able to release the drug rapidly. Among all, the formulation F12 batch Orodispersible tablets were considered to be the best formulation which showed drug release upto 98.901% within 15 min and indicated rapid absorption, effective therapy and improved bioavailability.

Prasanth VV, Sidhyartha Sarkar, Sourav Tribedi, Rinku Mathappan and Sam T Mathew

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