Genetic Instability of Bat-25 and Bat-26 Loci in Ovarian Cancer in Senegal
Developing countries account for 72% of deaths from cancer in the world, this scourge is the third leading cause of death in these countries. Annual mortality in West Africa is estimated at 76.23%. In Senegal, ovarian cancer is the eighth largest cancer for all sexes combined; its incidence is estimated at 2.5% in 2018. Most of these cancers are due to either chromosomal instability (80%) or associated to a failure to repair nucleotide mismatches. The general objective of this study is to understand the impact of the instability of microsatellite loci on ovarian carcinogenesis in Senegalese women. We studied the variability of the two loci (BAT25 and BAT26) by PCR/sequencing in 37 Senegalese patients with ovarian cancer. Analysis of the BAT25 and BAT26 loci polymorphism reveals that ovarian carcinogenesis is associated with instability of microsatellite loci with an MSI-H phenotype. This MSI-H instability is characterized at the tumor level by deletions, insertions, and substitutions. The instability of the BAT-26 marker is characterized by 10 patterns. BAT-25 mutations are more prominent. Ovarian carcinogenesis could be due to a defect in the MMR system.
Oumar Mane, Fatimata Mbaye*, Mbacké Sembene
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