Research Article Open Access

Impact of Epilepsy and Giardia Intestinalis Infection on the Gut Microbiome in Canine Species

Abstract

The role of the gut microbiome in host health is of growing interest, as it plays various roles in maintaining homeostasis. The composition of the microbiome has been shown to be associated with factors such as age, race, gender, geographical distribution, and genetic features. However, the full extent of the interaction between the gut microbiome and the host remains unknown. Compared to humans, there have been limited studies conducted on the gut microbiome of companion animals. In this study, we analyzed the canine gut microbiome using the National Center for Biotechnology Information (NCBI) SRA database. A total of 982 SRA data, comprising 1.22 TB, from 8 countries were included. Distance-based redundancy analysis (dbRDA) revealed a strong correlation between the presence of Peptoclostridium and epilepsy, and between the presence of Fusobacterium and Giardia intestinalis infection. Through network analysis using spearman rank-based correlation coefficient (ρ), we identified potential biomarkers by examining interactions within the genera lists. The results indicate that the composition of the canine gut microbiome varies with disease-specific microbes, suggesting that these species lists could serve as candidate biomarkers for epilepsy and Giardia intestinalis infection.

Chan-Yeong Park, Sung-Seok Lee, Hyun-Hee Seo, Dong-Uk Ha, Ha-Da Jang, Hyun-Ah Yu, San Kim*

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