Research Article Open Access

In silico Analysis of Role Played by CD3D Gene in the Pathogenesis of Multiple Sclerosis

Abstract

The Neuro degenerative disease Multiple Sclerosis (MS) is characterized by the progressive demyelination of cells in the Central Nervous System. The damage in the myelin is caused by the patient’s own autoimmunity. The immune cells for some unknown reasons find this protective coating of the neuronal cells as their target and degrades it. The T cells such as Th1, Th17 and Treg cells influences the pathogenesis and progression of the disease. In order to find out the likely cause for the abnormality in antigen recognition and in the characteristics of T cells, the In silico genomic analysis using the Gene Expression Omnibus (GEO) is conducted on the microarray database. The genes such as PDPK1, CD40LG and CD3D were found to be differently expressed. Amongst which the CD3D (CD3δ) gene is focused as the target gene for its effective contribution in TCR signalling. In this study, the detailed analysis of pathways that included CD3D gene, using Bioinformatic tools and databases is conducted. The CD3D (CD3δ) gene plays a vital role in the signal transduction by TCR-CD3 complex and there by influences in the selection and differentiation of T cells. Therefore, this study suggests that any defect in CD3D remains as the potential cause for the pathogenesis of Multiple Sclerosis.

Janani Thangapandian

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