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In- vitro Anti-Cancer Screening of Solanumindicum Rhus succedanea, Rheum emodiand Gardenia gummifera Medicinal Plants in Cancer Cells.

Abstract

The anticancer activities of Solanumindicum, Rhus succedaneum, Rheum emodi, and Gardenia gummifera medicinal plants from the methanolic extracts were determined by using in-vitroMTT cytotoxicity assay in various cancer cell lines human non-small cell lung carcinoma(H1975), prostatecarcinoma (PC-3and DU145), colorectal carcinoma (HCT116) and malignant melanoma (A375). The in-vitrocytotoxicity assay revealed that S. indicum, R. succedanea, R. emodi and G. gummifera extracts had strongest cytotoxicity with IC50 of 8.48 ∞g/ml,24.5∞g/ml, 28.24∞g/ml and 28.61∞g/ml respectively in DU145 cells and also with IC50 of 11.18∞g/ml, 11.04 ∞g/ml, 11.05 ∞g/ml and 23.03∞g/ml respectively in PC-3 cells. Whereas these extracts exhibited cytotoxicity with IC50 of 9.03∞g/ml, 7.71∞g/ml, 15.95 ∞g/ml and 11.71∞g/ml respectively in H1975 cells. Similarly all these extracts showed cytotoxicity with IC50 of 17.58∞g/ml,8.87∞g/ml,19.31∞g/ml and 11.67 ∞g/ml respectively in HCT116 cells. Finally methanolic extracts of these extracts exhibited cytotoxicity with IC5027.94 ∞g/ml, 13.13∞g/ml, 11.05 ∞g/ml and 7.816∞g/ml respectively in A375 cells. Our results revealed that methanolic extract of S. indicum, R. succedanea, R. emodi, and G. gummifera had profound cytotoxic effectand further studies to be initiated for potential herbal formulations to be used as an alternative of chemotherapeutic drugs due to less toxic to normal cells.

Sumantha Malur Gopalakrishna, Girisha Sirangala Thimappa, Ramesh Puttalingaiah Thylur, Yogisha Shivanna, and Anand Sreenivasan

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