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Preparation and Characterization of Gatifloxacin Encapsulated Chitosan Nanoparticles for Ocular Drug Delivery

Abstract

The science of chemical bondings and compositions has spread its advantages in different fields, including the area of drug delivery. The change in the interaction caused due to miniaturisation in size has lead to outstanding achievements in the field of drug delivery. Chitosan nanoparticles have gained more attention as drug carriers because of their better stability, simple preparation and versatile routes of administration. The ophthalmic antibiotic Gatifloxacin have several disadvantages such as rapid tear turnover, resulting in pre corneal loss and lacrimal drainage. But, encapsulation of the same within chitosan nanoparticles has been encouraged in order to increase their half life period and decreasing the dosage of the drug administered. The preparation method for synthesis of chitosan nanoparticles cross linked with TPP sodium tripolyphosphate was optimized and characterization was carried to check the particle size distribution and surface morphology and topography. The AFM image showed 56 nm sized Chitosan nanoparticles while the average size of the chitosan drug loaded particles was found to be around 150-180nm. The drug loaded chitosan nanoparticles showed increase in sensitivity towards Staphylococcus aureus and Staphylococcus epidermidis with satisfactory Drug Entrapment Efficiency of 84.9%.

Sharulata Ravisankar, Nibedita Dey, Aru Prakash Francis, Pandian K, T. Devasena

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