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Protective and Prophylactic Role of Brassicaceae Vegetables Extracts on N-nitrosodiethylamine Induced Initiation of Hepatocellular Carcinoma in Rat Liver

Abstract

Nitrosamine compounds are known hepatic carcinogens. In the metabolism of nitrosamines, such as diethylnitrosamine (DEN), there is evidence of the formation of reactive oxygen species (ROS) resulting in oxidative stress, which may be one of the factors in the etiology of cancer. The formation of ROS may alter the antioxidant system, through measuring essential and non-essential amino acids, the study was undertaken to investigate the Protective and Prophylactic role of ethanolic extracts of Brassica oleracea or botrytis (200 mg of plant extracts/kg body weight) on diethylnitrosamine (DEN) (1 μl/100 g b.wt.) in rats, induced initiation of hepatocellular carcinoma in rat liver, Brassicaceae vegetables are also recognized as a rich source of nutrients such as vitamins, minerals, amino acids (for example, L-alanine, L-aspartic acid, L-glutamic acid, L-glutamine, L-histidine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, and L-valine) Brassicaceae vegetables have been reported to have anticancer and antioxidant properties.

Sanaa A. Ali1, Samia A. Ahmed and Abdel Razik H. Farrag

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