Renal Clearance and Urine Output Reduction in Treated Rats
The Renin-Angiotensin System (RAS) is one of the most essential systems to maintenance blood pressure and body fluid volume and regulate kidney function. Angiotensin (Ang) 1-7 antagonizes both vascular and tubular actions of Ang II and exerts its vasodilatory, natriuretic, and diuretic effects by activating the Mas Receptor (MASR). In animal models of hypertension such as two-kidney-one-clip hypertensive (2K1C), Ang 1-7 was found to prevent the development of hypertension.
Samira Choopani, Mehdi Nematbakhsh
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