Synthesis and Characterization of Zeolitic Imidazolate Framework-8 Nanoparticles for Loading and Controlled Release of Cefazolin Drug
In recent decades, due to the spread of various diseases that have endangered human health, as well as due to inefficiency and less effectiveness and side effects of existing drugs and treatments, special attention has been paid to new treatments. One of these methods is the use of drug carriers. To this end, in this study, the ZIF-8 NPs were synthesized. These nanoparticles were characterized by FT-IR, TGA, SEM, BET, Zeta Potential, and UV-visspectroscopy. After synthesis, cefazolin drug was loaded on these nanoparticles. The drug loading amount was 12.54%. Then drug release in phosphate buffer with pH=7.4 was investigated. The release rate was 82.61%, which is excellent. These outcomes demonstrated that ZIF-8 nanoparticles have good potential for the controlled release of cefazolin.
Lida Hassanzadeh, Aziz Babapoor, Ali Nematollahzadeh
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