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Synthesis and Evaluation of Novel 1, 5- Benzothiazepine Derivatives as Anti- Inflammatory Agents

Abstract

Novel 1, 5-benzothiazepine derivatives were synthesized and characterized by spectral studies. The newly synthesized compounds (4a–g) were screened for in vivo anti-inflammatory activity at a dose of 10 mg/kg BW. Among those tested, compounds 4c, 4d and 4g exhibited significant anti-inflammatory activity in models of acute inflammation such as rat paw edema, while compounds 4c and 4g showed considerable activity compared with diclofenac as a standard drug.

Ganesh R. Mhaske, ShivdasS. Bajod, DamodharM. Ambhore and Sharad N. Shelke

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