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Synthesis of N-(substituted phenyl) pyrrolidine-2-carboxamide as Novel Anticonvulsant Agents

Abstract

In present investigation a series of N-(substituted phenyl) pyrrolidine-2-carboxamide derivatives were synthesized and were evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) test in mice. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Most of the compounds were found to be active in MES tests without any neurotoxicity. Compounds 3a and 3d were found the most active of the series without any neurotoxicity and less CNS depressant effect as compared to standard drug carbamazepine.

Mohamed Jawed Ahsan, and Mohd Amir

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