Research Article Open Access

Synthesis of P-Sulfonato Calix[4]Resorcinarene and its Complexation Ability with Caffeine

Abstract

Synthesis of novel and versatile calix[4]Resorcinarene and P-sulfonato calix[4]Resorcinarene {p-SC[4]R} in the modern field of supramolecular chemistry which is also well known as host-guest chemistry. Here Psulfonato calix[4]Resorcinarene act as supramolecular host and caffeine act as a guest molecule. The new 1:1 stoichiometry complex formation of caffeine–{p-SC[4]R} has been investigated. The aim of this work is to explored the supramolecule “P-sulfonato calix[4]Resorcinarene” as a drug delivery vehicle for the caffeine. From the last few decades caffeine citrate (cafcit) is used for the treatment of breathing problems of inborn babies (20 mg of caffeine citrate is equivalent to 10 mg of caffeine base). Its encapsulation directly delivers the caffeine base into the body which makes the synthesised soluble supramolecule as a versatile drug delivery molecule which can enhance its activity in various aspects.

Sumit Gangopadhyay

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