Research Article Open Access

Synthesis of Some Novel 6-Nitro-8-Pyridinyl Coumarin And 6-Nitro-8-Pyranyl Coumarin Derivatives and Evaluation of Their Anti-Bacterial Activity

Abstract

Two novel series of 4-methyl-6-nitro-8-(pyridin-2-yl)-2-oxo-2Hchromen- 7-yl benzoates VI-VIII and 4-methyl-6-nitro-8-(pyran-6-yl)-2-oxo-2Hchromen- 7-yl benzoates IX-XI were synthesized starting from the 8-acetyl- 4-methyl-6-nitro-2-oxo-2H-chromen-7-yl benzoate V. All synthesized compounds were evaluated for their antibacterial activity using paper disc diffusion technique and agar dilution technique. Among of the tested compounds, the 8-(6-Amino-4-(2-bromophenyl)-5-thio-carbamoyl-4Hpyran- 2-yl)-4-methyl-6-nitro-2oxo-2H-chromen-7-yl benzoate Xh displayed the most promising antibacterial activity with MIC of 64, 512 and 128 μg/ ml against B. subtilis, S. aureus and E. coli, respectively

Radwan El-Haggar, Ola Nosseir, Riham M Shawky, Nageh Abotaleb, Tamer Nasr

To read the full article Download Full Article | Visit Full Article