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The Toxicity of 3-Monochloro-1,2-Propanediol (+) on Activated T Cell in Mice

Abstract

This study aimed to clarify the toxicity effects of 3-monochloro-1,2- propanediol(+) (3-MCPD(+)) on activated T cell in mice. The toxicity effects of 3-MCPD (+) on murine T lymphocyte responses were evaluated in vitro and in vivo. The data showed that 3-MCPD(+) markedly inhibited ConA-induced T lymphocytes proliferation, Th1/Th2 cytokines production, activated Ca2+/ CaM/I-κB-NF-κB and Ca2+/CaM/CaN/NFAT signal transduction pathways in vitro. Furthermore, administration of 3-MCPD significantly inhibited T cell-mediated DTH response in vivo. These observations indicated that 3-MCPD (+) exhibited suppressive effects on activated mouse T cell in vitro and in vivo.

Shuang Guan, Sitong Ma, Linli Xu, Tong Wang, Mengrou Ren, Xuming Deng, Jing Lu*

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