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X-Ray Attenuation Coefficients for Pharmaceutical Drugs: A Qualitative Analysis by Non Destructive Technique

Abstract

The mass attenuation coefficient of drug was determined at low photon energies ranging from 8 keV to 44 keV using High Purity Germanium (HPGe) detector for the samples of different firms with similar Active Pharma Ingredient (API). Diclofenac sodium tablet is an oral suspension belongs to the NSAIDs group. The qualitative analysis of this opted pharmaceutical drug manufactured by different pharma companies viz., Diclomol, Dynapar, Voveran Plus and Diclogesic, were carried out by use of nondestructive method, through the determination of mass attenuation coefficient (MAC). The obtained results were compared with the theoretical WinXCom values, which gives the light on the quality analysis of the drug. This method confirms that the mass attenuation coefficient can be used as a qualitative analysis of any drug, which is a non-destructive technique compared with other techniques/methods wherein the sample is totally destroyed. Hence evaluation of a quality of the drug of from different companies is discussed in view of the MAC.

Manjunath A, and BR Kerur

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