Research & Reviews: Journal of Material Sciences
MenuISSN:2321-6212
ISSN:2321-6212
Daniel Li, Yaoyi Huang, Hong Shen, Yunlong Ma, Decheng Wu and Yuanzheng Ma
Northwestern University, USA 309th Hospital of the PLA, China
Posters & Accepted Abstracts: Res. Rev. J Mat. Sci
Bone infections are disastrous complications associated with orthopaedic implants such as prosthetic joints and fracture fixation devices. Local inflammation results osteolysis and destruction of the surrounding soft tissues. Management of such infections remains a significant challenge to clinicians, especially given the global rising prevalence of total joint arthroplasty. Current treatment regimens involve surgical debridement along with a prolonged course of antibiotics, which lacks bacterial and risks systematic toxicity to the patient. The efficacy of localized drug delivery, such as antibiotic-infused bone cement, is limited due to having only an initial burst release effect without a controlled, sustainable release profile. The ability to load antibiotics within a hydrogel scaffold to act as a drug delivery mechanism demonstrates promise in addressing this issue. In this study, we describe the fabrication of a vancomycin-loaded, polyethylene glycol (PEG) based hydrogel film covalently attached to titanium implant surfaces. Alginate microspheres were incorporated into the hydrogel to better control the rate of drug release. Specifically, this attenuates the initial burst release and delivers the drug at a more uniform rate by inhibiting hydrogel swelling. The resulting implants proved to be biocompatible and demonstrated minimal burst release, offering a consistent rate of drug elution for approximately four weeks in vitro. The rate of drug release could also be controlled by adjusting the amount of vancomycin loaded and hydrogel thickness. Material analysis characterized vancomycin dispersion kinematics as a function of the fabrication process. Antibiotic-loaded hydrogel coatings for titanium implants offer a unique drug delivery mechanism that maintains a sustained rate of drug release. In vivo studies are necessary to determine biodegradative properties of the material and the extent of antimicrobial activity against targeted organisms. Recent Publications 1. Butler B A, Fitz D W, Lawton C D, Li D, Balderama E S and Stover M D (2018) Early diagnosis of septic arthritis in immunecompromised patients. Journal of Orthopaedic Science 23(3):542-545. 2. Li D, Pengfei L, Linfeng F, Huang Y, Yang F, Mei X and Wu D (2017) The immobilization of antibiotic-loaded polymeric coatings on osteoarticular ti implants for the prevention of bone infections. Biomaterials Science 5(11):2337�2346. 3. Li D, Li L, Ma Y, Zhuang Y, Li D, Shen H, Wang X, Yang F, Ma Y and Wu D (2017) Dopamine-assisted fixation of drugloaded polymeric multilayers to osteoarticular implants for tuberculosis therapy. Biomaterials Science 5(4)730-740. 4. Kuiken T A, Bennet B A, Sharkey T, Ivy A D, Li D and Peabody T D (2017) Novel intramedullary device for lengthening transfemoral residual limbs. Journal of Orthopaedic Surgery and Research 12:53. 5. Fu S, Rossero J, Chen C, Alzgheir R, Li D and Takoudis C (2017) On the wetting behavior of ceria thin films grown by pulsed laser deposition. Applied Physics Letters 110:8.
Daniel Li has completed his Undergraduate degree in Materials Science and Engineering at University of Illinois. He conducted research under John Rogers Research Group investigating novel biodegradable electronics. He has participated in a wide variety of both basic and clinical research regarding biomaterials in the context of orthopaedic applications, such as the use of hydrogels as a novel drug-eluting mechanism to combat osteomyelitis and tuberculosis infection. He has spent significant time overseas in the orthopaedics department at the 309th Hospital of the PLA in Beijing, China, working under the team of Dr Yuanzheng Ma. Currently, he is performing clinical outcomes research at Northwestern University regarding the evaluation of prosthetic joint infection.
E-mail: Daniel.li1@northwestern.edu