Research & Reviews: Journal of Chemistry
Menue-ISSN: 2319-9849
e-ISSN: 2319-9849
TeYu Chen
Biogen, USA
ScientificTracks Abstracts: Research & Reviews: Journal of Chemistry
A useful protocol for achieving decarboxylative cross coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo(hetero) arenes is reported. This pragmatically focused study employs a unique Ag-Ni electrocatalytic platform to overcome numerous limitations that have plagued this strategically powerful transformation. In its opti- mized form coupling partners can be combined in a surprisingly simple way: open to the air, technical grade solvents, an inexpensive ligand and Ni source, substoichiometric AgNO3, proceeding at room temperature in about 2 hours with a simple commercial potentiostat. Most importantly all of the results are placed into context by benchmarking with state-of-theart methods. Applications are presented that simplify synthesis and rapidly enable access to challenging chemical space. Finally, adaptation to multiple scale regimes, ranging from parallel mgbased synthesis to decagram recirculating flow is presented.
As a medicinal chemist with experience in Neuroscience, I focus on using complex organic synthesis to develop and enhance the SAR of various scaffolds with the eventual goal of developing small molecule clinical candidates in the CNS field. I lead Biogen High throughput Parallel Medicinal Chemistry (PMC) synthesis platform - support projects teams from Hit ID to Lead Op discovery phase with the design, quick feasibility studies, and fast turn-around of focused matrix libraries. Establish internal capabilities to optimize standard library-type reaction conditions to support the above PMC efforts. In the meantime, I closely collaborate with project teams and computational chemists to develop PMC enable chemistry for CNS compound design and synthesis and cross-functionally with discovery biologists, quantitative biologists, and DMPK teams to achieve our goals.