Theranostic and Bioimaging via Rare-Earth Doped LuPO4 Nanoparticles

Applied Nanotechnology Summit

December 06, 2022 Webinar

Thomas Justel

FH Munster University of Applied Sciences, Germany

Keynote: RRJET

Abstract

The worldwide numbers of novel cancer cases increase steadily. Mostly, radiotherapy is for the treatment, while the therapy has many side effects and is thus exhausting for the patient. Therefore, a strong need exist to find improved radiation therapy with an improved therapeutic window and less side effects. For cancer tissue detection, a rather new approach is the imaging of cancer cells upon using Eu3+ and Tb3+ (co-) doped LuPO4 nanoparticles. The intense red emission of Eu3+ between 592 and 696 nm is well suitable for the detection of cancer cells in-vivo. In addition, the emission wavelength can be shifted from green via orange to red by co-doping with Tb3+. Furthermore, the emission depends on the excitation wavelength during diagnositcs, i.e. it can tuned from green to red. For firsts tests, Eu3+ doped LuPO4 nanoscale particles (100 nm) were injected into a culture of A549 lung cancer cell line and subsequently irradiated with a UV LED (365 nm). Moreover, an idea for an improved radiation therapy method compared to the traditional approach was investigated.

Biography

Thomas Jüstel received his Ph.D. in coordination chemistry in 1995 in the group of Prof. Dr. K. Wieghardt (Faculty of Chemistry). He was hired by the Philips Research Laboratories Aachen in summer 1995 as a research scientist, where he started to work on luminescent materials. Some years later he became a Senior Scientist; then he was promoted to a Principal Scientist in 2003. In spring 2004 he became a professor of Inorganic Chemistry and Material Sciences at the Münster University of Applied Sciences in Germany. His current research at the University deals with nanoscale materials and novel luminescent compositions for LEDs, UV radiation sources, and X-ray detectors. His work has been published in about 270 papers and has led to 100 granted US patents on inorganic luminescent materials and their application in detectors, fluorescent lamps, plasma displays, and solid state light sources (LEDs and OLEDs).

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