COVID-19 (SARS-CoV-2) outbreak has caused a worldwide emergency, spreading effectively and rapidly because of one of the most monstrous pandemics in mankind's history. This Special Issue means to incorporate top notch inquire about on both the pathophysiological parts of COVID-19 and its clinical presentation attributes. Specific consideration will be offered both to comorbidities and new pathophysiological speculations. Every single clinical issue, including sexual orientation contrasts, hereditary inclination, clinical and moral parts of triage, crisis and serious medication, and randomized controlled preliminaries, researches will be considered to be acknowledge in the coined special Issue.