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Volume 6 Research & Reviews: Journal of Material Sciences CrystalloPolySci 2018
November 19-20, 2018
4th International Conference on
Crystallography & Novel Materials
&
9th International Conference on
Biopolymers & Polymer Sciences
November 19-20, 2018 Bucharest, Romania
Francisco Fabio Oliveira de Sousa et al., Res. Rev. J Mat. Sci. 2018, Volume 6
DOI: 10.4172/2321-6212-C9-038
Biopharmaceutical and functional activities improvement by drug-biopolymers association
Francisco Fabio Oliveira de Sousa, Walter de Souza Tavares, Alberto Gomes Tavares Júnior and Manuel Martin-Pastor
Federal University of Amapa School of Pharmacy, Brazil
Zein is a biodegradable protein found in the maize endosperm (Zea mays). In the pharmaceutical industry, it has been used
as a coating agent in solid forms and in the composition of drug delivery systems, where it has shown the ability to entrap
drugs, lipids and geneticmaterial, promoting their controlled release. Its biological potential has gained attention lately.Thus, the
antioxidant and antimicrobial activities of zein solely have been identified, but barely explored. The associations of biopolymers
to drugs could result in synergistic or additive effects, depending on the structure, solubility, partition coefficient and chemical
interactions to the other compounds, resulting in new outcomes. In view of the biological properties of zein, we assessed the
improvement in the antimicrobial and antioxidant activities of this biopolymer when associated to some phenolic bioactive,
such as Ellagic Acid (EA). Their chemical association was accessed by 1H saturation Transfer-Difference Nuclear Magnetic
Resonance (STD-NMR) to explain these outcomes. The micro dilution method was used to assess the minimum inhibitory
and bactericide concentrations. The antioxidant activity was determined using the 2, 2-diphenyl-1-picryl-hydrazila free radical
scavenging method. EA has shown inhibitory activity against Staphylococcus aureus and Pseudomonas aeruginosa and an
antioxidant IC50 of 0.079 mg/mL. Zein has shown antimicrobial and antioxidant activities itself and enhanced synergically the
antioxidant and the antimicrobial activity against P. aeruginosa when combined with EA. 1H STD-NMR experiment confirmed
the formation of a complex between EA and zein that could be related with the improvement on its biological performance
over the individual compounds.
Biography
Francisco Fabio Oliveira de Sousa has completed his PhD from University of Santiago de Compostela, Spain and Postdoctoral studies from Federal University of
Ceara School of Dentistry, Brazil. He is the Director of Experimental and Clinical Pharmacy research group with 9 PhD and undergraduate students, coordinating
different projects in pharmaceutical technology and biomaterials. He has published more than 10 papers in reputed journals and has been serving as an Editorial
Board Member for many journals. In 2018, he has been awarded the Scientific Yearly Prize by the Brazilian Council Research.