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Volume 5, Issue 6 (Suppl)
J Mat. Sci.
ISSN: 2321-6212
Advanced Materials 2017
October 26-28, 2017
OCTOBER 26-28, 2017 OSAKA, JAPAN
13
TH
INTERNATIONAL CONFERENCE ON
Advanced Materials and Nanotechnology
Oxidative catalytic activity from the cysteinyl bolaamphiphile assembly with hemin cofactor
Chaemyeong Lee and Sang-Yup Lee
Yonsei University, Republic of Korea
A
s a facile way to organize the amino acids in an ordered structure, self-assembly of amphiphilic molecules with amino
acid motifs are very attractive. Here, we utilize the arrangement of amino acid segments of the amphiphilic molecules for
the preparation of an enzyme-mimetic catalyst. Use of the amino acid as a hydrophilic segment of an amphiphilic molecule
would lead the ordered arrangement of the amino acid on the surface of the assembled structure. To exploit this molecular
arrangement, we synthesized cysteinyl bolaamphiphiled and dissolved them in water to induce self-assembly. The assembled
structure was combined with hemin, a biological cofactor, to implement oxidative catalytic activity like the Horseradish
Peroxidase (HRP). The prepared HRP-mimetic catalyst acts as a radical initiator together with hydrogen peroxide to promote
the oxidation of the substrate. The performance of the catalyst was examined by the oxidation reaction of Acid Orange 7 (AO7),
a well-known organic dye. The catalytic activity was analyzed from the color change of AO7. The self-assembled structure of
cysteinyl bolaamphiphiles offered a protein-like platform on which various biological cofactors can bind to display biochemical
activities.
Biography
Chaemyeong Lee has graduated from the Department of Biology of Chonnam National University. She has received her MS degree in Department of Chemical and
Biomolecular Engineering at Yonsei University. She is currently a PhD candidate in the same university. Her main research interests include colloid, self-assembly
nanomolecules and surface modification.
esther2cm@gmail.comChaemyeong Lee et al., J Mat. Sci. 2017, 5:6
DOI: 10.4172/2321-6212-C1-009