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conferenceseries
.com
Volume 5, Issue 6 (Suppl)
J Mat. Sci.
ISSN: 2321-6212
Advanced Materials 2017
October 26-28, 2017
OCTOBER 26-28, 2017 OSAKA, JAPAN
13
TH
INTERNATIONAL CONFERENCE ON
Advanced Materials and Nanotechnology
Layer-by-layer self-assembly nanoparticles designed for resveratrol delivery
Antonio Ribeiro
Coimbra University, Portugal
R
esveratrol (RSV) is a non-flavonoid polyphenol which exhibits a wide array of beneficial multi-target biological effects in
preclinical studies. Besides this evidence, the far-reaching application of RSV is strongly hampered due to a low favorable
pharmacokinetics behavior attributed to its poor water solubility. This way, an unmet need to develop proper RSV delivery
systems is posed, aiming for the enhancement of its bioavailability
in vivo
. An advanced formulation strategy able to surpass
this limitation is nanotechnology, whereby Layer-By-Layer (LbL) self-assembly nanoparticles assume particular emphasis. LbL
self-assembly is an encapsulation technique which is built on the sequential assembly of oppositely charged polyelectrolytes
upon charged low soluble drug nanoparticles’ surface. Tunned nanocapsule type constructions at nanoscale are obtained,
fundamentally comprising a drug nano-core which is covered by a polyelectrolyte-based multilayered nanoshell. Herein,
LbL self-assembly technique coupled with a washless polyelectrolyte approach was developed. Aqueous RSV nanoparticles
composed of distinct bilayers of Polyallylamine Hydrochloride (PAH) as the poly-cation and Dextran Sulfate (DS) as the
poly-anion, were performed (including, 2.5 (RSV-(PAH/DS)
2.5
), 5.5 [RSV-(PAH/DS)
5.5
] and 7.5 [RSV-(PAH/DS)
7.5
] bilayers).
Homogenous particle size distributions with 150-250 nmwere obtained.Themost complex formulation, composed 7.5-bilayers,
evidenced 219±1 nm and 0.17 of polydispersity index; high electrical surface of +31±0.5 mV and a high drug content of
92±2%. The modulation of the composition of the coating shell allowed the control of the RSV release pattern. Owing to such,
these LbL nanoparticles are considered as a promising vehicle for the delivery of RSV.
Biography
Antonio Ribeiro has completed his PhD from Rene Descartes University in France. He is a Board Member of UC-Tecnimede, an industrial-university consortium
basef in Coimbra and focused on new delivery systems. He has published more than 60 papers in peer-reviewed reputed journals and several hundreds of
communications around the world. He has also been serving as an Editorial Board Member of reputed journals.
aribeiro@ff.uc.ptkmh@ameslab.gov
Antonio Ribeiro, J Mat. Sci. 2017, 5:6
DOI: 10.4172/2321-6212-C1-008