53 / 53
Page 80
Notes:
conferenceseries
.com
Volume 5, Issue 6 (Suppl)
J Mat. Sci.
ISSN: 2321-6212
Advanced Materials 2017
October 26-28, 2017
OCTOBER 26-28, 2017 OSAKA, JAPAN
13
TH
INTERNATIONAL CONFERENCE ON
Advanced Materials and Nanotechnology
pH sensitive amphiphilic polypeptide prodrug for NIR imaging-guided combined photodynamic
therapy and chemotherapy
Zheng Ruan and Lifeng Yan
University of Science and Technology of China, China
P
hotodynamic Therapy (PDT) is a promising clinical modality for the treatment of tumors and non-malignant nidus. A 4,
4-difluoro-4-bora-3a, 4a-diaza-sindacene (BODIPY) core based Photosensitizer (PS) has many of the ideal characteristics
of a PDT agent, such as a high extinction coefficient, resistance to photo-bleaching and high ratios of light-dark toxicity which
couldalsobe recognizedas dye for bio-imaging.However, theBODIPYmentionedabove cannot bedispersed inaqueous solution
since it is hydrophobic and therefore needs a BODIPY-carrier so that the PDT agent can be delivered and then released in the
areas of tumors to kill cells. And few researchers have combined chemotherapy using DOX with a photosensitizer which shows
great lethality to cancer cells like HepG2 and eminent bio-imaging ability. Owing to the significant acidic microenvironments
of tumor tissues and low pH (~5.0) inside cancer cells, we have innovatively tried to synthesize hydrazine based pH-sensitive
peptide within PEG shells and entrapped by the novel NIR-BODIPY photosensitizer using DOX for anticancer curing. The
integration of chemotherapy and PDT has met the rising necessity of combination for clinical diagnosis. All the polymeric
micelles are of suitable size for the EPR effect and can be easily disassembled in an acidic microenvironment to release the
DOX or BODIPY for cancer treatment. The polypeptide itself shows great biocompatibility to cells, while severe damage to
HepG2 cancer cells was caused by micelles with BODIPY and DOX which have also shown well NIR-imaging ability. All those
advantages above mean that dual-agent pH-sensitive polypeptides may be promisingly applied in future medical cures in a
combination of PDT and chemotherapy.
Biography
Zheng Ruan is a full Professor of physical chemistry at School of Chemical and Material Science, University of Science and Technology of China (USTC). His
research focuses on biomaterials and biomedicine based on polymers. He has published over 120 papers and edited two books. He has served on many Editorial
Boards of journals and is currently on several including Fine Chemicals, Coal and Fine Chemicals, Science Letters, etc.
rzchn@mail.ustc.edu.cnZheng Ruan et al., J Mat. Sci. 2017, 5:6
DOI: 10.4172/2321-6212-C1-008