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Research & Reviews: Journal of Material Sciences | ISSN: 2321-6212 | Volume 6
Theoretical, Materials and Condensed Matter Physics
5th International Conference on
November 26-28, 2018 | Los Angeles, USA
Characterization of ferrite nanoparticles and application for theranostics
Magnetic nanoparticles have drawn attention recently due to their interesting nanoscopic features and potential applications
for not only recording electric materials but also in the biomedical field. Previously, we obtainedmonodispersive magnetic
nanoparticles (MNPs) by an original wet chemical method and reported magnetic, structural and thermal properties. Local
structure analysis by X-ray absorption fine structure (XAFS) was useful to estimate nanoscale materials. We also suggested
some biomedical applications using MNPs after functionalization. These functional MNPs were further introduced into cells.
Furthermore, cancer cell selective MNPs were developed. Based on these techniques, we proposed a therapeutic method of
magnetic hyperthermia. Now we propose “theranostics” by development nanoparticles for diagnostic and therapeutic materials
simultaneously. For the therapeutic part, several kinds of ferrite NPs were prepared and AC magnetic measurements were
performed. The relationship between the imaginary part of magnetic susceptibility χ” and the increase in temperature in the
AC field was estimated. We have carried out in vitro experiments using cultured human breast cancer cells, and a drastic
hyperthermia effect was observed. As one of the diagnostic method, mass spectrometric imaging (MSI) was proposed. With
this method, the targeting analyte can be detected only with the nanoparticles as matrices, and simultaneously we can see the
distribution of the materials by mapping the spectra. By means of our matrices, targeting analyte of very low molecular weight
was successfully detected. Furthermore, effective parameters for MRI contrast agent, signals of the third harmonic components
for magnetic particle imaging (MPI) were observed.
Biography
Yuko Ichiyanagi is an Associate Professor at Yokohama National University since 2009 (Applied Physics) and Osaka University since 2017. She was invited and
chaired at several international conferences. Now she has published more than 50 papers and books. has been serving as an International Advisory Committee
Member of some reputed conferences.
Yuko Ichiyanagi
Yokohama National University, Japan
Yuko Ichiyanagi, Res. Rev. J Mat. Sci. 2018, Volume 6
DOI: 10.4172/2321-6212-C10-040