23 / 26
Page 61
June 28-29, 2019 | Oslo, Norway
Volume 08
Journal of Medical and Health Sciences | ISSN : 2319-
Breast Pathology and Cancer, Gynecology and Obstetrics Pathology, Palliativecare and Gerontology 2019
Joint Event
Breast Pathology & Cancer
Palliativecare & Gerontology
Gynecology and Obstetrics Pathology
Immunohistochemical (IHC) study of ER and PR status in breast carcinoma in women of
Pakistan
Muhammad Zohaib Qamar
Pakistan
Objective:
The main objective of the present study is to determine the association between estrogen (ER)
and progesterone (PR) expression status along with histological grade of tumor in invasive ductal carcinoma
(IDC) of breast in Pakistani patients.
Study Design:
Experimental and observational study.
Materials &Methods:
One hundred and six cases of various histologic types of breast cancer were included
during two year period (January 2015 to December 2016), conducted at Histopathology Department of
Chughtai Lahore Lab (Pvt.) Lahore Pakistan. We evaluated age, histologic tumor type, histologic tumor
grade, ER estrogenic and PR progesterone receptors status by immunohistochemistry (IHC) along with
information regarding tumor histologic grade of tumor in relation with status of estrogen receptor (ER) and
progesterone receptor (PR) receptors status from breast cancer patients suffering from breast cancer.
Results:
Results showed that 80% of cases were evaluated as invasive ductal carcinoma; remaining 20%
cases included as other histologic tumor types. The age ranges from 23 years to 82 years. Twenty one patients
<40 years with mean age of 32 years and 84 patients were >40 years of age with mean age of 55 years were
recorded. Majority of the tumors were seen to be having grade II (56.6%) followed by grade III tumors
(20.8%). However, no case was seen to be involved with grade I tumor. Positive expression of estrogen
receptor (ER) and progesterone receptor (PR) expression are seen in 62% and 49% patients respectively.
Conclusion:
In current study, age distribution among 106 patients concluded that women more than 40 years
old had the highest higher incidence of breast carcinoma. Most dominant tumor type was invasive ductal
carcinoma (IDC). Furthermore estrogen (ER) and progesterone (PR) positivity manifested more drift towards
tumors of grade II tumors in comparison to tumors of grade I and grade III tumors.
RRJMHS 2019, Volume 08