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.com
Volume 5, Issue 5
Res. Rev. J Mat. Sci. 2017
ISSN: 2321-6212
Advanced Materials 2017
September 07-08, 2017
September 07-08, 2017 | Edinburgh, Scotland
Advanced materials & Processing
11
th
International Conference on
Novel and versatile solid-state chemiluminescnce sensor based on TiO
2
-Ru(bpy)
3
2+
nanoparticles for
pharmaceutical drugs detection
Mohamed O. Amin, Entesar Al-Hetlani
and
Metwally Madkour
Kuwait University, Kuwait
T
his work describes a novel and versatile solid-state sensor for analytes detection using Ru(bpy)
3
2+
-Ce(IV). Herein, we report
the synthesis, characterization, optimization and application of a new type of hybrid nanoparticles (NPs). Mesoporous TiO
2
-
Ru(bpy)
3
2+
NPs were prepared using a modified sol-gel method by incorporating Ru(bpy)
3
2+
into the initial reaction mixture at
various concentrations. The resultant bright orange precipitate was characterized via: TEM, N
2
sorpometry, ICP-OES, Raman and
UV-Vis spectroscopy techniques. The concentration of Ru(bpy)
3
2+
complex in the NPs was quantified and its chemiluminescnce (CL)
response was compared to the same concentration in the liquid phase using oxalate as model analyte. The results showed that this type
of hybrid material exhibited higher CL signal compared to the liquid phase due to enlarged surface area of the hybrid NPs (~149.6
m²/g). The amount of TiO
2
-Ru(bpy)
3
2+
. NPs and the effect of the oxidant flow rate were also investigated to optimize the CL signal.
The optimized system was further used to detect oxalate and two pharmaceutical drugs; imipramine and promazine. The linearity of
both drugs was in the range of 1-100 pM with limits of detection (LoD) of 0.1 and 0.5 pM, respectively. This approach is considered
simple, low cost, facile and can be applied to a wide range of analytes.
Biography
Mohamed O. Amin is a graduate of Kuwait University and currently pursuing an MSc in medicinal chemistry. Despite being passionate about medicinal chemistry
he is always looking for other research opportunities in other research laboratories in Kuwait University. This quest for knowledge and experience lead him to
work in Dr. Al-Hetlani and Dr. Madkour laboratory and learn about nanomaterials synthesis, characterization and vast range of applications. He has published his
first research paper in the area of photocataysis using TiO
2
NPs. Furthermore, He participated in using this type of nanomaterial as solid support for detection
applications namely, chemiluminesscnce (CL) due to their large surface area. This work is the first of its kind in the area of solid state CL and was used for the
detection of oxalic acid and two pharmaceutical compounds achieving enhanced LoD.
mohamed.o.amin@hotmail.comMohamed O. Amin et al., Res. Rev. J Mat. Sci. 2017, 5:5
DOI: 10.4172/2321-6212-C1-006
Figure1:
A schematic representation
of the newly synthesised solid-
state TiO2-Ru(bpy)32+ NPs as a
new approach chemilunminescnce
sensor for analyte detection