46 / 48
Page 102
conferenceseries
.com
November 13-15, 2017 | Las Vegas, USA
14
th
International Conference and Exhibition on
Materials Science and Engineering
RRJOMS | Volume 5 | Issue 7 | November, 2017
Self-assembled pectin-conjugatedmulti-arm-polyethylene glycol nanoparticles loading dihydroartemisinin
for anticancer combination therapy
Yanxue Liu
Beijing Forestry University, P. R. China
S
ingle-drug therapy for cancer is greatly hampered by its poor water-solubility, difficulties in controlling and predicting the drug
release, and non-specific delivery to the target tissue that limited to the clinical application. In order to overcome these limitations,
a novel self-assembled nanoparticle platform based on pectin-multi-arm-polyethylene glycol-dihydroartemisinin conjugate (Pec-
Multiarm-PEG-DHA) was first presented. This conjugate was synthesized by introducing hydrophobic drugs dihydroartemisinin to
hydrophilic polymer molecules eight-arm polyethylene glycol, and then was linked to pectin via ester linkages. Moreover, another
anticancer drug hydroxycamptothecin (HCPT) was encapsulated into the self-assembled nanoparticles (Pec-Multiarm-PEG-DHA/
HCPT NPs). The obtained nanoparticles possessed appropriate size (~ 85 nm), high drug-loaded efficiency (~9.12 wt% DHA),
encapsulation efficiency (~ 12.11 wt% HCPT), good stability and pH-dependent. The time-dependent cytotoxic of the Pec-Multiarm-
PEG-DHA/HCPT NPs was only 4% 4T1 cell and 2% MCF-1 cell survived after 72 h. Pec-Multiarm-PEG-DHA/HCPT NPs exhibited
a higher cytotoxicity, longer blood retention time of free drug (8.0-fold DHA, 7.4-fold HCPT) and more effective cellular uptake
than free drugs. 4T1 tumor-bearing mice treated with the nanoparticles also showed a 90.6% survival advantage in comparison with
15.5% free DHA and14.1% free HCPT. In addition, it is clearly an elaborate certification that nanoparticles could reduce the risk
of hypersensitivity reactions substantially. Therefore, Pec-Multiarm-PEG-DHA/HCPT NPs is a promising potential for anticancer
combination therapy.
Liuyanxue2015@bjfu.edu.cnRes. Rev. J Mat. Sci. 2017, 5:7
DOI: 10.4172/2321-6212-C1-012