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conferenceseries
.com
Volume 5, Issue 6 (Suppl)
J Mat. Sci.
ISSN: 2321-6212
Advanced Materials 2017
October 26-28, 2017
OCTOBER 26-28, 2017 OSAKA, JAPAN
13
TH
INTERNATIONAL CONFERENCE ON
Advanced Materials and Nanotechnology
Abi-functional graphene oxide nanohybrid for photo-stimulated nitric oxide release and photothermia
Marta Perez Lloret, Nino Marino, Salvatore Petralia, Martina Gallo, Jiri Mosinger, Sabrina Conoci and Salvatore Sortino
Università degli Studi di Catania, Italy
G
raphene Oxide (GO) is a novel low-cost material, presenting intriguing proprieties. Obtained by oxidation of graphite,
graphene oxide is a hydrophilic and so water-soluble biocompatible compound, making it the perfect candidate in the
design of nanocarriers. The presence of hydroxyl, epoxy and carboxyl groups on its surface enables its easy functionalization
and high loading capacity (circa 200% in some cases). In addition, it presents photo-thermal activity, which means it is able to
convert light absorbed into heat. Photo-Thermal Therapy (PTT) is an emerging discipline envisaged for Cancer and Antibiotic
treatments. The photo production of cytotoxic species, known as Photodynamic Therapy (PDT), presents several advantages,
such as good spatiotemporal release control, fast reaction rates and the absence of residues after the reaction. Nitric Oxide
(NO) is an example of those species, which can have beneficial or deleterious effect, depending on the concentration. This short
half live radical presenting reduced distance diffusion in cellular environment does not suffer Multidrug Resistance (MDR).
Here resides the interest of combining light-controlled NO release with suitable nanocarriers. Covalent link of a nitro-aniline
derivative nitric oxide photo donor to nanoGO results in a bimodal nanoplatform that combine light-controlled NO release
with photo-thermal proprieties.
References
1.E B Caruso, S Petralia, S Conoci, S Giuffrida and S Sortino (2007) Photodelivery of Nitric Oxide from Water-Soluble Platinum Nanoparticles.
J. Am. Chem. Soc
.; 129: 480-481.
Biography
Marta Perez Lloret has completed her MSc at Universidad de Zaragoza, Spain and currently she is pursuing PhD in the project Cyclon-Hit from MSCA at Università
degli Studi di Catania, Italy.
martaperezlloret@gmail.comMarta Perez Lloret et al., J Mat. Sci. 2017, 5:6
DOI: 10.4172/2321-6212-C1-008