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Research & Reviews: Journal ofPharmaceutical Analysis | ISSN : 2320-0812 Euro Pharma Chemistry & Future Pharma 2019
June 27-28, 2019 | Amsterdam, Netherlands
12th World congress on Joint Event
4 th Pharmaceutical Chemistry Conference Future Pharma
Volume 08
Rahul Kumar et al., Pharmaceutical Analysis 2019, Volume 08
Pharmacotherapy of migraine prophylaxis: Effectiveness in reducing
attack frequency
Pharmacological prophylaxis for migraine consists of a long list of drugs. Beta
blockers, antidepressants, antiepileptics, calcium channel blockers, pregabalin,
levetiracetam, etc. The main drugs utilized for a long time and a number of studies
have been conducted to investigate their efficacy inmigraine prophylaxis. To assess
the effectiveness of well-known drugs and some newer ones we searched last five-
year, original research articles onMEDLINE, Google Scholar andEMBASE on 15th
February 2019. We selected randomized or quasi-randomized trials of drugs used
in migraine prophylaxis. We didn’t compare each of them but searched for their
effectiveness individually. Percentage reduction in attack frequency was evaluated.
We found 41 studies out of which we include 14 studies. We excluded animal
studies, abstract with only papers and studies with missing data. Amitriptyline
was found to be most effective ranging from 60% to 83%. Sodium valproate was
the most studied drug with 60% to 78% reduction in attack frequency after two
months. Pregabalin showed 65% reduction in attack frequency after two months
treatment. Levetiracetam found to be effective by 58% to 70% reduction in attack
frequency. Flunarizine effectiveness ranges from 46% to 76%. Erenumab (a human
monoclonal antibody which blocks calcitonin gene related receptor) also showed
50% reduction in attack frequency. Fremanezumab (quarterly administration) is
moderately effective with 40% reduction in attack frequency. Reduction in attack
frequency was 63% by melatonin. Omega 3 polyunsaturated fatty acids showed
66% reduction in attack frequency. We may conclude that in reducing migraine
attack frequency, older drugs are more effective though newer one also seems to
be promising.
Biography
Rahul Kumar has completed his MBBS from GSVM Medical College, Kanpur, India and
MD from SN Medical College, Agra, India. He is an Associate Professor in Pharmacology
Department at King George’s Medical University, Lucknow, India. He has published more than
10 papers in reputed journals.
Rahul Kumar
King George’s Medical University
India
Co-Author
Sarvesh Singh, Anil Kumar Saksena,
Narendra Kumar, Akhlaque Ahmad and
Manoj Kumar
King George’s Medical University, India