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Euro Pharma Chemistry & Future Pharma 2019
Volume 08
Research & Reviews: Journal ofPharmaceutical Analysis | ISSN : 2320-0812
June 27-28, 2019 | Amsterdam, Netherlands
12th World congress on
Joint Event
4
th
Pharmaceutical Chemistry Conference Future Pharma
Therapeutic potentials of conypododiol
Habibullah Jan
1
, Roohullah
2
, Inamullah Khan
3
, Adnan Shahidullah Khan
4
and
Muhammad Samie
5
1
Abdul Wali Khan University, Pakistan
2
Abasyn University, Pakistan
3
University of Peshawar, Pakistan
4
Drug Regulatory Authority of Pakistan, Pakistan
5
COMSATS Institute of Information Technology, Pakistan
Background:
The purpose of this research is to investigate the anti-pyretic, anti-inflammatory and
antinociceptive effects of conypododiol fromAsparagus adscendens. Natural products are used from centuries
for different ailments. The majority of drugs isolated from plants have shown good results. It is also reported
that most of synthetic drugs have severe unwanted effects. Efforts are made to investigate bioactive plants for
introduction and development of drugs having efficacy and the least side effects. The investigations carried
out were successful and the compound showed good results.
Objectives:
The main objective of this study is to investigate anti-inflammatory, anti-pyretic and
antinociceptive effects of conypododiol.
Methods:
Brewer’s yeast method for pyrexia, paw oedema-modelling, acetic acid induced test for writing
and the increasing-temperature hot plate test method were performed.
Results:
Different strengths of conypododiol were applied and compared with standard drugs like diclofenac,
tramadol, paracetamol and indomethacin. Diclofenac (10 mg/kg) and conypododiol (20 mg/kg) significantly
inhibit nociceptive sensation in writhing test. The compound in (40 mg/kg) showed 58.97% inhibition in
writhing test for investigation of antinociceptive effect. Tramadol (10 mg/kg) and conypododiol (20 mg/
kg) significantly inhibit the nociceptive sensation in pain model (hot plate test). Paracetamol (150 mg/
kg) and conypododiol (40 mg/kg) significantly (P<0.01, P<0.05) inhibit pyrexia in yeast induced pyrexia
model. Similarly, conypododiol exhibited anti-inflammatory activity in paw edema modelling and 40 mg/kg
markedly effective i.e. 91.92% inhibition.
Conclusion:
The results showed that conypododiol possess the effects like anti-inflammatory, anti-nociceptive
and anti-pyretic. So the plant confirms the indigenous utility against inflammation, pyrexia and pain.
Pharmaceutical Analysis 2019, Volume 08