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Euro Pharma Chemistry & Future Pharma 2019
Volume 08
Research & Reviews: Journal ofPharmaceutical Analysis | ISSN : 2320-0812
June 27-28, 2019 | Amsterdam, Netherlands
12th World congress on
Joint Event
4
th
Pharmaceutical Chemistry Conference Future Pharma
Design, synthesis, molecular docking, molecular characterization and biological activity of
novel synthetic peptide derivatives
Gaber O Moustafa
National Research Centre, Egypt
O
ur interest in the design, synthesis and biological investigations of peptides is, progressively,
reported. Herein, the search for potent biological agents presented and updated area of the organo-
biochemical literature. Herein, Nα-1, 3-benzenedicarbonyl linear peptide candidates, has the structure:
Nα-1, 3-benzenedicarbonyl-bis-(Amino acids)-X. On the other hand, Nα-benzenedicarbonyl bridged cyclic-
penta-peptides, having the structure: Cyclic-[Nα- benzendicarbonyl- bis-(dipeptide)-L-Lys]-Y. Variable
synthetic coupling methods, in solution, as well as experimental reaction conditions, were experimented.
The candidates were, chromatographically purified and spectroscopically characterized. A preliminary
cytotoxicity evaluation, against eight human cancer cell lines was realized (National Cancer Institute, Egypt).
The detailed cytotoxic and hepatotoxic results, compared to those of five common anticancer drugs and their
biochemical assays particularly, as histone deacetylase inhibitors, are currently in progress. Structure activity
relationships were outlined and suggested prospective were proposed.
Pharmaceutical Analysis 2019, Volume 08