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Euro Pharma Chemistry & Future Pharma 2019
Volume 08
Research & Reviews: Journal ofPharmaceutical Analysis | ISSN : 2320-0812
June 27-28, 2019 | Amsterdam, Netherlands
12th World congress on
Joint Event
4
th
Pharmaceutical Chemistry Conference Future Pharma
Synthesis, characterization, antibacterial and cytotoxicity activities of eugenol derivatives
Asnuzilawati Asari
1
, N H C A Rahim
1
, N Ismail
1
and
H Osman
2
1
Universiti Malaysia Terengganu, Malaysia
2
Universiti Sains Malaysia, Malaysia
E
ugenol is one of the phenylpropanoids available in nature, which possess a variety of medicinal properties.
In this study, a series of eugenol derivatives were synthesized and characterized by normal spectroscopic
techniques of FTIR, UV-Vis, NMR and MS. All the synthesized compounds were further evaluated for their
anti-bacterial and cytotoxicity activities. The anti-bacterial activity were tested via well-diffusion method
against gram-positive
(Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis)
and gram-
negative (
Escherichia coli
and
Staphylococcus typhimurium
) bacteria. Eugenol derivatives showed broad
spectrum for anti-bacterial activity with compound 67 emerged as the potential anti-bacterial agent since it
was susceptible for both gram-positive and negative bacterial strains. The
in vitro
cytotoxicity was assayed
against hepatocellular carcinoma (HepG2) cells using MTS Cell Proliferation Assay Kit (Calorimetric)
for selected derivatives (11, 61 and 67); among three tested compounds, 61 exhibited cytotoxicity against
targeted cells line with IC50 values of 12.5 µg/ml.
Pharmaceutical Analysis 2019, Volume 08