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Euro Pharma Chemistry & Future Pharma 2019
Volume 08
Research & Reviews: Journal ofPharmaceutical Analysis | ISSN : 2320-0812
June 27-28, 2019 | Amsterdam, Netherlands
12th World congress on
Joint Event
4
th
Pharmaceutical Chemistry Conference Future Pharma
Effects of ascorbic and cinnamic acids on the albumin glycation level in breast cancer patients
Israa G Zainal, Fatima Karar
and
Mohsin O Mohammed
Kirkuk University, Iraq
G
lycation is the non-enzymatic interaction of carbohydrates with proteins. It is considered as a factor that
leads to Alzheimer's disease, diabetes, aging, neuropathy, cancer, and atherosclerosis.
In vitro
and
in vivo
glycation was studied with human and bovine serum albumin as a model of the protein. Aconcentration of 0.1
M glucose was used as a glycation agent. The level of the Amadori product was determined by thiobarbituric
acid calorimetric assay after hydrolysis. Advanced glycation end products (AGEPs) were measured by UV-
visible spectrophotometry. Different concentrations of ascorbic acid (vitamin C) and cinnamic acid were
found to be potent inhibitors of both the subsequent end products and the glycation reaction. The result
showed that, the level of glycation in breast cancer patient is significantly high and ascorbic and cinnamic
acids as inhibitors decreased the glycation reaction of albumin.
Pharmaceutical Analysis 2019, Volume 08