12 / 28
Pathology 2018
Research & Reviews: Journal of Medical and Health Sciences
ISSN: 2319-9865
Page 67
October 08-09, 2018
Edinburgh, Scotland
17
th
International Conference on
Pathology & Cancer
Epidemiology
W
e have previously demonstrated that uterine cervical
mixed carcinomas with adenoid cystic differentiation are
high-risk human papillomavirus (HPV) related but pure adenoid
cystic carcinomas (ACCs) of vulvar and uterine cervical origin
appear to be unrelated to high risk HPV and contain NFIB related
chromosome translocation. However, data on clinicopathologic
features and survival outcomes of ACCs in lower female genital
tract are limited to case reports and small case series studies.
Here we systemically analyzed 84 cervical ACCs and 71 vulvar
ACCs to identify clinicopathologic features and survival factors
in a population based surveillance, epidemiology and end results
study. While cervical ACCs tended to occur in the elderly (median,
72 years), vulvar ACCs commonly occurred in the patients a
decade younger (median, 59 years, p<0.001). The median size of
cervical and vulvar ACCs were 3.3 cm and 3.4 cm respectively.
The patients with cervical and vulvar ACCs tended to have higher
stage disease and a significant proportion of these patients
received radiotherapy with or without surgery. The patients with
cervical ACC had poor prognosis compared to that of vulvar ACC.
The 10-year cause specific survival (CSS) rates for patients with
cervical ACC were 57.9% and vulvar ACC are 80.7% (p<0.001).
Increased age and high stage were significantly associated with
a worse prognosis in the patients with cervical and vulvar ACCs
by univariate and multivariate analysis. Our data demonstrated
the distinctive clinicopathologic features and survival outcomes
differing significantly among ACCs in lower female genital tract,
thus providing a rationale for location/pathologic type-based
treatment modalities.
dxing2@jhmi.eduDistinctive clinico-pathological features and disease-specific
survival of adenoid cystic carcinomas in the lower female
genital tract
Deyin Xing
The Johns Hopkins University School of Medicine, USA
RRJMHS 2018
Volume: 7